Category Archives: Senior Faculty Talks

Faculty Talks with Kenneth L. Madsen’s group

Following a summer vacation, we present the next Neuroscience.rocks seminar featuring Kenneth Lindegaard Madsen together with his two PhD students Thorvald Faurschou Andreassen and Simon Erlendsson.

Wednesday, August 19 at 16:00 in the Faculty Club

Program

  • 16:00: Kenneth will give an introduction to scaffolding proteins in the post synaptic density and synaptic plasticity.
  • 16:20: Thorvald will be speaking about “Investigating Cellular Activity and protein trafficking in Dissociated Neuronal Cultures fluorescent biosensors”.
  • 16:35: Simon will talk about Molecular scaffolding from the inside out – using inverted membrane sheets to quantitatively probe scaffolding.

After the talks, refreshments will be served. Please share the word with your collegues. We are looking forward to seeing you all there.

Kenneth L. Madsen’s group

Research
Our research addresses fundamental aspects of basic pharmacology, molecular pharmacology and neuropharmacology, with certain potential translational parts. We aim to better understand neuronal cell biology with particular focus on protein trafficking and signalling processes in the synthetic and endocytic pathway as well as molecular interactions with expert knowledge on, protein-lipid interactions as well as protein-protein interactions.

Work Package 1 is focused on the pharmacology of PSD95/Disc-large/ZO-1 homology (PDZ) mediated proteins-protein interaction and how these domains might represent new attractive pharmacological targets as alternatives to surface receptors.

Work Package 2 will seek to explore the controversial idea that trafficking of receptors and transporters, which in many cases is strongly integrated with their pharmacology, is determined not only by protein-protein interactions, but also by yet unappreciated protein-lipid interactions that govern localization of the receptors and transporters to areas of high membrane curvature in the plasma membrane.

Work Package 3 is aimed at obtaining fundamental new understanding of dopamine signaling processes in the brain. Evidently, this has broad pharmacotherapeutic perspectives given the key role of dysfunctional dopamine signaling in many brain disease including schizophrenia, bipolar disorder, ADHD, Parkinsons’ Disease and drug abuse.

Methodologies
Molecular biology, protein purification, receptor binding, advanced light microscopy, including live microscopy and fluorescence energy transfer microscopy (FRET), trafficking assays of integral membrane proteins using ELISA and confocal microscopy.

For further information, visit Kenneth L. Madsen’s INF-website.

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