Author Archives: Peter Petersen

Faculty Talks with Kenneth L. Madsen’s group

Following a summer vacation, we present the next Neuroscience.rocks seminar featuring Kenneth Lindegaard Madsen together with his two PhD students Thorvald Faurschou Andreassen and Simon Erlendsson.

Wednesday, August 19 at 16:00 in the Faculty Club

Program

  • 16:00: Kenneth will give an introduction to scaffolding proteins in the post synaptic density and synaptic plasticity.
  • 16:20: Thorvald will be speaking about “Investigating Cellular Activity and protein trafficking in Dissociated Neuronal Cultures fluorescent biosensors”.
  • 16:35: Simon will talk about Molecular scaffolding from the inside out – using inverted membrane sheets to quantitatively probe scaffolding.

After the talks, refreshments will be served. Please share the word with your collegues. We are looking forward to seeing you all there.

Kenneth L. Madsen’s group

Research
Our research addresses fundamental aspects of basic pharmacology, molecular pharmacology and neuropharmacology, with certain potential translational parts. We aim to better understand neuronal cell biology with particular focus on protein trafficking and signalling processes in the synthetic and endocytic pathway as well as molecular interactions with expert knowledge on, protein-lipid interactions as well as protein-protein interactions.

Work Package 1 is focused on the pharmacology of PSD95/Disc-large/ZO-1 homology (PDZ) mediated proteins-protein interaction and how these domains might represent new attractive pharmacological targets as alternatives to surface receptors.

Work Package 2 will seek to explore the controversial idea that trafficking of receptors and transporters, which in many cases is strongly integrated with their pharmacology, is determined not only by protein-protein interactions, but also by yet unappreciated protein-lipid interactions that govern localization of the receptors and transporters to areas of high membrane curvature in the plasma membrane.

Work Package 3 is aimed at obtaining fundamental new understanding of dopamine signaling processes in the brain. Evidently, this has broad pharmacotherapeutic perspectives given the key role of dysfunctional dopamine signaling in many brain disease including schizophrenia, bipolar disorder, ADHD, Parkinsons’ Disease and drug abuse.

Methodologies
Molecular biology, protein purification, receptor binding, advanced light microscopy, including live microscopy and fluorescence energy transfer microscopy (FRET), trafficking assays of integral membrane proteins using ELISA and confocal microscopy.

For further information, visit Kenneth L. Madsen’s INF-website.

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Faculty Talks With Martin Lauritzen’s group

We proudly present the first Neuroscience.rocks seminar featuring Martin Lauritzen together with his post docs Sanne Barsballe Jessen and Krzysztof Kucharz.

Thursday, May 28 at 16:00 in the Faculty Club.

Program

  • Martin will give an introduction about his laboratory’s research.
  • Sanne  will be speaking about “Gamma activity and neurovascular coupling in aging – electrophysiology and two-photon imaging in vivo” .
  • Krzysztof  will talk about “The neuronal endoplasmic reticulum fission-fusion. 2-photon imaging and characterization of the novel phenomenon in vivo” .

After the talks, refreshments will be served. We are looking forward to seeing you all there.

Martin Lauritzen’s group

Research
How is the brain powered? And what goes wrong when we age, or suffer from a neurodegenerative disorder? The lab’s research is focused on determining the relation between function, signalling (information processing), energy turnover and energy supply in the nervous system of normal and aged rodents, and in animals with a neurodegenerative disease.

Techniques
The laboratory use a combination of techniques to study neuroenergetics: electrophysiological techniques to record spike activity from single cells and local field potentials. This is combined with electro-chemically recorded oxygen consumption, assessment of local blood flow with double-wavelength laser-Doppler flowmetry, and multi-photon microscopy for in vivo measurements of calcium dy-namics in rats and mice, including genetically modified animals.

For further information, visit Martin Lauritzen’s INF-website.

Startup meeting for neuroscience.rocks

We are two young researchers who have long felt the need for a platform for both scientific and social interactions among the young neuroscientists at the Department of Neuroscience and Pharmacology. Therefore we have created neuroscience.rocks: a community for the young researchers, to help enhance interactions across fields of research, give a better insight into the research taking place at the department, and provide opportunities for collaborations across research groups.

We would therefore like to invite you for a short presentation of the idea and open up for a discussion. If you want to hear more, contribute or show your support, you should come to the meeting, which will take place Friday, February 20th, at 12:00 in room 18.6.56a. Everybody is welcome – from bachelor students to postdocs. The Deputy Head of Department, Jakob Balslev Sørensen, and perhaps Head of the Department, Mette M. Rosenkilde, will also attend the meeting.

Below are some of the activities we suggest to be a part of neuroscience.rocks:

Senior faculty talks
Monthly seminars with talks by group leaders from the department. The talks should be based on a recent publication with a solid presentation of the field and the background of the study. The duration of the talks should be 30-50 minutes, and they should be focused for students and young researchers. Serving of pizza/soda/beer dependent on the time. E.g. thursdays at 16:00.

Monthly distinguished seminars
Possibility of co-organising the monthly seminar by the junior and senior faculty of the department, combined with a lunch for students interested in a casual meeting with the invited speaker.

Other possibilities
Social events, industry visits/presentations.

Welcome to Neuroscience.rocks

Neuroscience.rocks is a forum for young researcher in neuroscience in Copenhagen.  It was established to create a community across the Department of Neuroscience and Pharmacology to enhance interactions across fields of research and as a platform for social interactions among young neuroscientists.